320 Comments

Is that you, Devin?

Expand full comment

If prayer could preserve you from Covid, why didn't it work for the Black Death? No nation in the 21st Century is going to out-pray the medieval Europeans, who had no distractions or alternative answers provided by science to the question of why? The only answer they had was "because God made it so", so prayer was all they had. And back then the landscape was littered with thousands of monasteries and nunneries stuffed with people whose full time job was prayer.

Expand full comment

I agree about CEOs. Short-term thinking is baked into today's corporations and businesses. But from what I've read, manufacturing countries actually are closing down and stuff is not being made. So the third-world factories are not necessarily making sick workers labor to their deaths. The machines aren't running because of COVID. But mostly I think the reasons you gave make sense: short-term thinking and investing and the lack of brain matter in CEOs.

Expand full comment

Q -- Two kittens on a roof, which one falls off?A -- The one with the lowest 𝛍 !

Expand full comment

Just ask Spain how that turned out

Expand full comment

the last report released showed them at about 400 deaths per day, around 8x the rate in say, CA. that is not good

Expand full comment

However bad good reporting says it is, the reality is probably worse. We'll never really know until we get an excess death analysis.

Expand full comment

Please expand on the purpose of apoptosis if it is not (among other things) a defense mechanism against genetic damage.

(edited to correct a typo.)

Expand full comment

You're assuming competence.

Expand full comment

I'm OK with some difference in income, up to five times as much seems doable. Anyone above 5 times the lowest wage gets taxed until they are exactly at 5 times the lowest wage and those taxes are sent to those with the lowest wages. That way we're tackling the problem from two sides.

Expand full comment

Compartimentalisation is the way out.

Expand full comment

When I hear "Mu" I think first of that book of pseudoscience by Churchward, The Lost Continent of Mu. I borrowed it from the library as a kid and couldn't get into it, despite being such a nerd. That's how bad and boring it was. Not half as bad as the current anti-vaxxer and conspiracy theories, though.

Expand full comment

(1) It serves to get rid of extra cells during development. This is the main function of apoptosis in nervous system development. The body makes about twice as many neurons as it needs, then kills off those that fail to make functional connections. (2) It serves as a way of getting rid of virus-infected cells. During a normal virus infection, the virus doesn't alter the genome, so this does not "protect the genome from virally induced alterations". (3) It serves as a way of getting rid of cancer cells. I suppose you could, at a stretch, call this a defense against genetic damage, but, in humans, cancer-causing genome mutations are not usually virus-induced.

I don't actually know, off the top of my head, of any cases of apoptosis serving "to protect the genome from virally induced alterations". In addition, I'm entirely mystified by the "going back to unicellular organisms..." part.

Your turn: Please give some specific examples in which apoptosis serves to protect the genome from virally induced alterations.

Expand full comment

Thank you for your reply.

I'm not your opponent, I was just curious since I only half-remembered some of this. Your clear distinction between 2 and 3 helped me clear my mind on the subject.

I think their mention of "going back to unicellular organisms..." was a reference to the age of this evolutionary development, though that sounds unlikely to me since there is no evolutionary benefit to a single celled organism commiting suicide. After all, dying seriously hampers your reproductive success. I'd be interested in their sources though, I might learn something.

Expand full comment

There are some cases of single-celled organisms committing suicide. For instance, some cellular slime mold cells suicide during the development of a fruiting body.

This is the closest thing I can find to apoptosis in unicellular apoptosis:Apoptosis in unicellular organisms: mechanisms and evolution.

Expand full comment

Interesting! I've recently seen a video (second video in a Stanford series on the biology of behaviour IIRC) about cooperation between two bacteria species, and I'm starting to rethink my definition of "multi-celled organism".

Expand full comment